well there are two types of API's supported... TMAPI and CCAPI, TMAPI requires a debugged eboot, CCAPI doesnt. Aslong as you have Control Console installed on your ps3 and pc you can RTE (Real Time Edit)! TMAPI pf course is better cause you actually can mod however CCAPI is just as good for beginners.
Tools now a days use CCAPI v2.50 which has been added to most tools and dlls u need to get the tool to work correctly.